Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates. [version 2; referees: 2 approved]

Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates. [version 2; referees: 2 approved]

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The centromeric protein CENP-C is a base component of the kinetochore.This protein, along with CENP-A has been shown to adaptively evolve in a number of animal and plant species.In order to determine if CENP-C also evolves in fish species, I attempted to retrieve fish CENP-C sequences from GenBank.No Teleostei CENP-C sequences were found either by name or by BLASTP searches with the vertebrate CENP-C motif sequence.A number Figurines of putative Teleostei protein sequences were identified in GenBank that have homology to the C-terminal cupin domain of vertebrate CENP-C.

These proteins only have partial homology to the CENP-C motif, but evidence is presented that makes it likely that these fish proteins are orthologs of CENP-C.Interestingly, it was also discovered that the CENP-C motif sequence is also mostly present in M18BP1 proteins of fish and Leisure CK100C210R Freestanding Ceramic 100cm Range Cooker in Cranberry some other vertebrates but not in mammals.This finding may have implications for CENP-C and M18BP1 assembly in centromeric regions of different vertebrate taxa.