2-O-METHYLMAGNOLOL, A MAGNOLOL DERIVATIVE, SUPPRESSES HEPATOCELLULAR CARCINOMA PROGRESSION VIA INHIBITING CLASS I HISTONE DEACETYLASE EXPRESSION

2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression

Magnolia officinalis is widely used in Southeast Asian countries for the treatment ORG NO CHICKEN NOODLE SOUP of fever, headache, diarrhea, and stroke.Magnolol is a phenolic compound extracted from M.officinalis, with proven antibacterial, antioxidant, anti-inflammatory, and anticancer activities.In this study, we modified magnolol to synthesize a

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Modified minimally invasive technique for decompression and reduction of thoracolumbar burst fracture with neurological symptoms: Technical Note

Abstract Purpose There are few reports about minimally invasive decompression and fixation for patients with thoracolumbar fracture and neurological symptoms.The previously reported method requires complete laminectomy, and removal of the medial part of the pedicle to expose the spinal canal for reduction.Thus, some approach-related damage to the b

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Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates. [version 2; referees: 2 approved]

The centromeric protein CENP-C is a base component of the kinetochore.This protein, along with CENP-A has been shown to adaptively evolve in a number of animal and plant species.In order to determine if CENP-C also evolves in fish species, I attempted to retrieve fish CENP-C sequences from GenBank.No Teleostei CENP-C sequences were found either by

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Generation of hiPSC lines from four glutaric aciduria type I (GA1) patients carrying pathogenic biallelic variants in GCDH

GCDH encodes for the enzyme catalyzing the sixth step of the lysine degradation pathway.Autosomal recessive variants in GCDH are associated with glutaric aciduria type I (GA1), of which a wide genotypic spectrum of pathogenic variants have been described.In this study, hiPSC lines derived Compression Socks from four GA1 patients with different geno

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